Seamless Astronomy — brings together astronomers, computer scientists, information scientists, librarians and visualization experts involved in the development of tools and systems to study and enable the next generation of online astronomical research.
Eye Wire — a citizen science game where you map the 3D structure of neurons.
Open Science is a Research Accelerator (Nature Chemistry) — challenge was: get rid of this bad-tasting compound from malaria medicine, without raising cost. Did it with open notebooks and collaboration, including LinkedIn groups. Lots of good reflection on advertising, engaging, and speed.
The Internet of Things That Do What You Tell Them: Cory Doctorow passionately explains how computers are already entwined in our lives, which means laws that support lock-in are much more than inconveniences.