- Patent on Medical Trial Design to Reduce Placebo Effect — drug companies say these failures are happening not because their drugs are ineffective, but because placebos have recently become more effective in clinical trials. [...] The whole idea that placebo effect is getting in the way of producing meaningful results is repugnant, I think, to anyone with scientific training. What’s even more repugnant, however, is that Fava’s group didn’t stop with a mere paper in Psychotherapy and Psychosomatics. They went on to apply for, and obtain, U.S. patents on SPCD. (via Ben Goldacre)
- OpenMalaria (Google Code) — an open source C++ program for simulating malaria epidemiology and the impacts on that epidemiology of interventions against malaria. It is based on microsimulations of Plasmodium falciparum malaria in humans, originally developed for simulating malaria vaccines. (via Victoria Stodden)
- Pricing Experiments You Might Not Know But Can Learn From — compendium of ideas and experiments for pricing.
- Retrominer — mining Bitcoins on a NES. I’m delighted by the conceit, and noticing that Bitcoin is now sufficiently part of the zeitgeist as to feature in playful hacks.
ENTRIES TAGGED "medicine"
Patenting Preventing Placebos, Simulating Malaria, Pricing Experiments, and Mining Bitcoin
Open Source Cancer Informatics, NPR Framework, Littery Junk, BitTorrent Sync
- Open Source Cancer Informatics Software (NCIP) — we have tackled the main recommendation that came out of our June meeting with open-source thought leaders: Keep it simple. Make barriers to entry as low as possible, and reuse available resources. Specifically, we have adopted a software license that is approved by the Open Source Initiative (OSI) and have begun to migrate the code developed under the cancer Biomedical Informatics Grid® (caBIG®) Program to a public repository. Our goal in taking these steps is to remove as many barriers as possible to community participation in the continuing development of these assets. Awesome! (via John Scott)
- NPR’s Framework for Easy Apps — their three architectural maxims: Servers are for chumps; If it doesn’t work on mobile, it doesn’t work; and Build for use. Refactor for reuse..
- Random Junk in People’s Labs (Reddit) — reminded me of the contents of my “tmp” and “Downloads” and “Documents” directories: unstructured historical crap with no expiration and no current use. (Caution: swearing in the title of the Reddit post) (via Mihalyi Csikszentmihalyi)
- Sync — BitTorrent’s alpha-level tech to “automatically sync files between computers via secure, distributed technology.” Not only is it “slick for alpha” (as one friend described), it’s bloody useful: I know at least one multimillion-dollar project built on their own homegrown implementation of this same idea. (via Jason Ryan)
Medical Data Commons, Verizon Sell You, Doctor Watson, and Weedkilling Drones
- Let’s Pool Our Medical Data (TED) — John Wilbanks (of Science Commons fame) gives a strong talk for creating an open, massive, mine-able database of data about health and genomics from many sources. Money quote: Facebook would never make a change to something as important as an advertising with a sample size as small as a Phase 3 clinical trial.
- Verizon Sells App Use, Browsing Habits, Location (CNet) — Verizon Wireless has begun selling information about its customers’ geographical locations, app usage, and Web browsing activities, a move that raises privacy questions and could brush up against federal wiretapping law. To Verizon, even when you do pay for it, you’re still the product. Carriers: they’re like graverobbing organ harvesters but without the strict ethical standards.
- IBM Watson About to Launch in Medicine (Fast Company) — This fall, after six months of teaching their treatment guidelines to Watson, the doctors at Sloan-Kettering will begin testing the IBM machine on real patients. [...] On the screen, a colorful globe spins. In a few seconds, Watson offers three possible courses of chemotherapy, charted as bars with varying levels of confidence–one choice above 90% and two above 80%. “Watson doesn’t give you the answer,” Kris says. “It gives you a range of answers.” Then it’s up to [the doctor] to make the call. (via Reddit)
- Robot Kills Weeds With 98% Accuracy — During tests, this automated system gathered over a million images as it moved through the fields. Its Computer Vision System was able to detect and segment individual plants – even those that were touching each other – with 98% accuracy.
Vannevar Bush, Topic Transparency, Ancient Maps, and Concussion Sensors
- As We May Think (Vannevar Bush) — incredibly prescient piece he wrote for The Atlantic in 1945.
- Transparency and Topic Models (YouTube) — a talk from DataGotham 2012, by Hanna Wallach. She uses latent Dirichlet allocation topic models to mine text data in declassified documents where the metadata are useless. She’s working on predicting classification durations (AWESOME!). (via Matt Biddulph)
- Slippy Map of the Ancient World — this. is. so. cool!
- Technology in the NFL — X2IMPACT’s Concussion Management System (CMS) is a great example of this trend. CMS, when combined with a digital mouth guard, also made by X2, enables coaches to see head impact data in real-time and asses concussions through monitoring the accelerometers in a players mouth guard. That data helps teams to decide whether to keep a player on the field or take them off for their own safety. Insert referee joke here.
The convergence of data, privacy and cost have created a unique opportunity to reshape health care.
Coffee Rings, Scaling Laws, Autonomous Aircraft, and Dreaming Computers
- The Coffee-Ring Effect (YouTube) — beautiful video of what happens in liquids as they evaporate, explaining why coffee stains are rings, and how to create liquids with even evaporative coating.
- The Importance of Quantitative Thinking Medicine (PDF) — scaling laws underly aging, metabolism, drug delivery, BMI, and more. Full of wow moments, like Fractals are a common feature of many complex systems ranging from river networks, earthquakes, and the internet to stock markets and cities. [...] Geometrically, the nested levels of continuous branching and crenulations inherent in fractallike structures optimise the transport of information, energy, and resources by maximising the surface areas across which these essential features of life flow within any volume. Because of their fractal nature, these effective surface areas are much larger than their apparent physical size. For example, even though the volume of our lungs is about 5–6 L, the total surface area of all the alveoli is almost the size of a tennis court and the total length of airways is about 2500 km. Even more striking is that if all the arteries, veins, and capillaries of an individual’s circulatory system were laid end to end, its total length would be about 100000 km, or nearly two and a half times around the earth.
- Autonomous Robotic Plane at MIT (YouTube) — hypnotic to watch it discover the room. A product of the Robust Robotics Group at MIT.
- Electric Sheep — hypnotic screensaver, where the sleeping computers collaborate on animations. You can vote up or down the animation on your screen, changing the global gene pool. Popular animations survive and propagate.
Personalized Medicine, Reporting on Execution, Software-Defined Radio, and Beyond Hadoop
- Personalized Leukemia Treatment (NY Times) — sequenced the tumor’s DNA, found the misbehaving gene, realized there was an existing experimental treatment to tackle that gene, and it worked. Reminds me of My Daughter’s DNA, which had its origin in the poignant story of Hugh Reinhoff sequencing his daughter’s DNA to diagnose her condition. It’s all about medical professionals now, but that’s no different from the Internet starting with geeks and moving out to the masses.
- Bullseye HD — web app which allows you to make the most of the time you spend with your team, by focusing your attention on the projects and actions that are off-track or not getting enough focus, rather than wasting precious time on status updates. (via Rowan Simpson)
- Per Vices — selling software-defined radio boards (for Linux only at the moment). (via Ars Technica)
- Post-Hadoop (GigaOm) — Google have moved beyond the basic software that Hadoop was copying. Lots of interesting points in this article, including one fundamental reality – MapReduce (and thereby Hadoop) is purpose-built for organized data processing (jobs). It is baked from the core for workflows, not ad hoc exploration.
Michael Italia on making use of data collected in health care settings.
Michael Italia from Children's Hospital of Philadelphia discusses the tools and methods his team uses to manage health care data.
Public Spending Links, Telemedicine Questioned, Comments Re-examined, and Informed Consent
- Stop Treating People Like Idiots (Tom Steinberg) — governments miss the easy opportunities to link the tradeoffs they make to the point where the impacts are felt. My argument is this: key compromises or decisions should be linked to from the points where people obtain a service, or at the points where they learn about one. If my bins are only collected once a fortnight, the reason why should be one click away from the page that describes the collection times.
- UK Study Finds Mixed Telemedicine Benefits — The results, in a paper to the British Medical Journal published today, found telehealth can help patients with long-term conditions avoid emergency hospital care, and also reduce deaths. However, the estimated scale of hospital cost savings is modest and may not be sufficient to offset the cost of the technology, the report finds. Overall the evidence does not warrant full scale roll-out but more careful exploration, it says. (via Mike Pearson)
- Pay Attention to What Nick Denton is Doing With Comments (Nieman Lab) — Most news sites have come to treat comments as little more than a necessary evil, a kind of padded room where the third estate can vent, largely at will, and tolerated mainly as a way of generating pageviews. This exhausted consensus makes what Gawker is doing so important. Nick Denton, Gawker’s founder and publisher, Thomas Plunkett, head of technology, and the technical staff have re-designed Gawker to serve the people reading the comments, rather than the people writing them.
- Informed Consent Source of Confusion (Nature) — fascinating look at the downstream uses of collected bio data and the difficulty in gaining informed consent: what you might learn about yourself (do I want to know I have an 8.3% greater chance of developing Alzheimers? What would I do with that knowledge besides worry?), what others might learn about you (will my records be subpoenable?), and what others might make from the knowledge (will my data be used for someone else’s financial benefit?). (via Ed Yong)
Randomized Trials for Policy, Crowdfunding Equity, Safe DIYBio, and Easy Unique Experiences
- Test, Learn, Adapt (PDF) — UK Cabinet Office paper on randomised trials for public policy. Ben Goldacre cowrote.
- UK EscapeTheCity Raises GBP600k in Crowd Equity — took just eight days, using the Crowdcube platform for equity-based crowd investment.
- DIY Bio SOPs — CC-licensed set of standard operating procedures for a bio lab. These are the SOPs that I provided to the Irish EPA as part of my “Consent Conditions” for “Contained Use of Class 1 Genetically Modified Microorganisms”. (via Alison Marigold)
- Shuffling Cards — shuffle a deck of cards until it’s randomised. That order of cards probably hasn’t ever been seen before in the history of mankind.